Cho SY, Shim SR, Rhee HY, et al. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease. Parkinsonism Relat Disord. 2012;18(8):948-52. View abstract. Eltahir Saeed WS, Gasim Khalil EA. Immune response modifying effects of bee venom protein [Melittin]/Autoclaved L. donovani complex in CD1 Mice: the search for new vaccine adjuvants. J Vaccines Vaccin. (2017) 08:6–11. doi: 10.4172/2157-7560.1000372 Sun Y, Han M, Shen Z, Huang H, Miao X. Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats. Saudi J Biol Sci. (2018) 25:213–9. doi: 10.1016/j.sjbs.2017.10.010 BV has been explored in cancer ( 111, 112); melittin is considered cytolytic but non-specific. Melittin can break down the membrane lipid bilayer and exhibits toxicity when injected intravenously ( 113). APi M has the ability to suppress tumor growth in breast, liver, prostate, and lung cancer cells ( 111, 112). In vitro and in vivo studies show that melittin can suppress growth of cancerous cells by inhibiting NF-κB signaling and activating caspase 3 and 9 pathways. Inhibition of hepatocellular carcinoma cell motility was observed in vitro and in vivo by suppression of Rac1-dependent pathways ( 114). Anti-inflammatory Potential

de Jong NW, Vermeulen AM, de Groot H. Allergy to bumblebee venom. III. Immunotherapy follow-up study (safety and efficacy) in patients with occupational bumblebee-venom anaphylaxis. Allergy 1999;54:980-4. View abstract. Almunia C, Bretaudeau M, Held G, Babon A, Marchetti C, Castelli FA, et al. Bee venom phospholipase A2, a good “Chauffeur” for delivering tumor antigen to the MHC I and MHC II peptide-loading compartments of the dendritic cells: the case of NY-ESO-1. PLoS ONE. (2013) 8:1–17. doi: 10.1371/journal.pone.0067645 What is Stearyl Alcohol? Stearyl alcohol is a natural fatty alcohol that is used as an emollient, em... Hider RC. Honeybee venom: A rich source of pharmacologically active peptides. Endeavour 1988;12:60-5.. View abstract.Babon A, Almunia C, Boccaccio C, Beaumelle B, Gelb MH, Ménez A, et al. Cross-presentation of a CMV pp65 epitope by human dendritic cells using bee venom PLA 2 as a membrane-binding vector. FEBS Lett. (2005) 579:1658–64. doi: 10.1016/j.febslet.2005.02.019 Sometimes our busy schedules don't let us squeeze in regular workouts. For a temporary body-toning solution in between workouts, massage Nip + Fab's been venom and shea butter infused Body Souffle all over your body to make your skin appear firmer and toned. Brilliant! This product made me skin look fresh with a healthy glow, sorted my skin problems like fine lines open pores.

I have been looking for a new eye cream for a while now and had high hopes for this Bee Venom. I have used Rodial products before and have found them very effective.i got this as a free sample which is just as well as the price point is high. I liked the texture but with such a small sample I wasn’t able to use it for long enough to be able to tell if it made a difference. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. (2020) 109:102433. doi: 10.1016/j.jaut.2020.102433 Biological Variability of Bee Venom Composition Among Bee Variants for Biotoxin Administration in Complementary MedicineHauser RA, Daguio M, Wester D, Hauser M, Kirchman A, Skinkis C. Bee-venom therapy for treating multiple sclerosis: a clinical trial. Altern Complement Ther. (2001) 7:37–45. doi: 10.1089/107628001300000714 Muller U, Thurnheer U, Patrizzii R, Spies J, Hoigne R. Immunotherapy in bee sting hypersensitivity: bee venom versus whole body extract. Allergy. (1979) 34:369–78. doi: 10.1111/j.1398-9995.1979.tb02006.x Memariani H, Memariani M, Moravvej H, Shahidi-Dadras M. Melittin: a venom-derived peptide with promising anti-viral properties. Eur J Clin Microbiol Infect Dis. (2020) 39:5–17. doi: 10.1007/s10096-019-03674-0

Quaresima V, Naldini MM, Cirillo DM. The prospects for the SARS-CoV-2 pandemic in Africa. EMBO Mol Med. (2020) 12:e12488. doi: 10.15252/emmm.202012488 Choi J, Jeon C, Lee J, Jang J, Quan F, Lee K, et al. Suppressive effects of bee venom acupuncture on paclitaxel-induced neuropathic pain in rats: mediation by spinal α2-adrenergic receptor. Toxins. (2017) 9:351. doi: 10.3390/toxins9110351 There is also research to suggest that bee venom may be beneficial to reducing the appearance and visibility of photoaging and wrinkles. Bee venom has been suggested to help decrease the level at which different pathways in the body are activated by the sun’s rays, specifically UVB. This may help to reduce the negative effects experienced within the skin when exposed to UV rays. While the mechanisms by which bee venom may help reduce the signs of aging , the studies suggest that bee venom may reduce some of the visible signs of aging. Is Bee Venom Safe?Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan Wang Y, Zhang D, Du G, Du R, Zhao J, Jin Y, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. (2020) 395:1569–78. doi: 10.1016/S0140-6736(20)31022-9 Chirumbolo S, Zanoni G, Ortolani R, Vella A. In vitro biphasic effect of honey bee venom on basophils from screened healthy blood donors. Allergy Asthma Immunol Res. (2011) 3:58. doi: 10.4168/aair.2011.3.1.58 Lim SM, Lee SH. Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: a systematic review and meta-analysis. J Integr Med. 2015;13(4):241-7. View abstract.