The main difference between Frontline Spot-On and Frontline Plus is that Frontline Plus contains an additional active ingredient, (S)-methoprene, which prevents flea eggs and larvae from developing. This means that Frontline Combo can provide more comprehensive protection against fleas, as it can help to break the flea lifecycle. In the absence of specific studies, the use of the product is not recommended in dogs younger than 8 weeks of age, or in dogs weighing less than 2 kg.

Nineteen percent of pet dogs and 84% of hunting dogs were infested with fleas at the beginning of the study, while 98% of all dogs were flea-negative 1 day after Frontline Tri-Act and NexGard Spectra administration. Four weeks later, 28% of hunting dogs again had flea burdens, but the authors noted most fleas were dead or moribund.Boehringer Ingelheim is a research-driven group of companies dedicated to the discovery, development, manufacture and marketing of innovative health care products. Section Overview At the beginning of the study, 19% and 84% of pet and hunting dogs, respectively, were infected with gastrointestinal nematodes, mostly consisting of Trichuris vulpis and Ancylostomatidae. Fourteen days after the first administration of Frontline Tri-Act and NexGard Spectra, 40% of hunting dogs continued to shed eggs. All pet dogs remained nematode-free from Day 14 until the end of the study, while several hunting dogs continued to shed hookworm eggs for the study’s duration. Prevents a flea infestation in your home when used every 4 weeks by killing fleas before they can lay eggs. Prevents a flea infestation in your home when used every 4 weeks by killing fleas before they can lay eggs

Clinically proven and formulated specifically for dogs, FRONTLINE Tri-Act® FOR DOGS is also water-resistant after 48 hours –so your dog can enjoy occasional swimming and bathing and still stay protected. Frontline Flea Spray dries within 5-10 minutes. It is a fast-drying product that can be applied to wet or dry fur. Clinically proven and formulated specifically for dogs, FRONTLINE Tri-act® FOR DOGS is also water-resistant after 48 hours –so your dog can enjoy occasional swimming and bathing and still stay protected.

Prevents a flea infestation in your home when used every 4 weeksby killing fleas before they can lay eggs. Frontline Tri-Act Spot-On usually dries within 2-4 hours. The active ingredients in Frontline Tri-Act Spot-On, fipronil and permethrin, are both fast-acting and the product dries within 2-4 hours of application. However, it is still important to avoid bathing your pet for at least 48 hours after application. Clinically proven and formulated specifically for dogs, frontline TRI-ACT® FOR DOGS is also water-resistant after 48 hours –so your dog can enjoy occasional swimming and bathing and still stay protected.