Telomerase is an enzyme which repairs/maintains telomeres, which are aprotective ends on the chromosome. And it is the chromosome which contains all of the DNA information required by your cells to healthfully replicate and function. Absolutely, you know, most skincare products on the market, are not actually based on science, the information comes from regurgitated blogs, or vloggers, and really outdated information, or they'll talk about a new ingredient.

How long should our readers run that self experiment? What is a long enough period to evaluate before and after? Do you have any direct evidence of before and after telomere length in this skin that shows TAM 818 is making skin telomeres grow longer? We assessed all the parameters after 6 weeks and 12 weeks. One of the most interesting results that we got from this study was an improvement in the skin barrier, which happened only on the side of the face that was treated with the OS-01 peptide. What matters, in the end, is your biological age, because that reflects the health of your tissue. We are always aiming to have a lower biological age. The good news is that biological age is changeable. Our clinical study was designed to be “split face”. So half of the face was treated only with the “basal” formula and half of the face with the formula plus the OS-01 peptide.

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Keep your skincare regime unchanged except for adding OS-01 to your protocol ( control your self-experiment)

The consequence of that is that your skin will look better. Our primary focus is on the health of the skin. That's why we like to use skinspan instead of other classic cosmetic terms. Why does skin age? Telomere dysfunction is now known to be one of the causes of aging. Within the skin, increasing amounts of evidence are linking telomere ‘attrition’ (shortening) to skin aging, but more research is needed to demonstrate the direct link between telomerase and improved skin health. They form as a result of UV damage, as the melanin coagulates beneath the skin surface, and will eventually lead to visible damage at the skin’s surface and are a sure sign that collagen is also being degraded. Third - consistency is key. It takes awhile to work out the right strategy for achieving the results you’re after, and if you’re not willing to put up the budget to keep the practice up for the long-haul, you might be better off not trying this one at all. If we are able to make that system continue to work efficiently, we can avoid that accumulation of damage that can lead to a more broad dysfunction of the tissue. OneSkin Replicates Aging in the Lab

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We've got all these exciting technologies coming up, but at the same time, the fundamentals we already know and understand. My first Visia scan and consultation with NextHeath were complimentary - so if you live in LA or have any travel plans through the area, your first choice is obvious! Here are two areas of action I will be experimenting with improve my aesthetic age before my next Visia scan. UV Damage LB:And to that point, the name of your company is actually based on some science, you've got this number in there - “ 818”. There's a fascinating scientific story behind where that number comes from. Could you tell us about that? Because the main harm of senescent cells comes not from the senescence cells themselves, but more from the of inflammatory signaling that spoils the surrounding cells, causing them to age faster.

LB:With this cell division, you are not naming names here, but we'll jump in there and say this is the premise of retinol of retinoids. That's one of the approaches that we could say that you're citing, which is again to take off that top layer of skin bring the new youthful skin cells to the surface. LB: Yes, you've talked about this in a couple other places. You've used the term “feed forward”. This is the concept of how senescent cells induce more senescence through inflammatory cytokines, creating a cascade of more accelerated aging.

At Longevity Blog, we help you sort through the hype and get down to the real results you want, by helping you to test before & after results yourself. Our job is to ask targeted questions of the founders and lead scientists at longevity tech companies, to help direct your personal investment into your own longevity strategy, effectively. Most valuably, the Visia scanning unit was not with out direct justification for this drastic improvement - and we’re going to look into the details as to what changed to create this improvement. So “topical supplement”, basically means a product that's designed to optimize the health of the skin. CR:Once you have senescence cells, there is a cascade of inflammatory signals leading to events such as collagen breakdown, which in turn will lead to a series of further dysfunctions in the skin. Most cosmetic companies that are testing “anti aging” products on human skin are using neonatal cells. Basically they're testing aging products in baby skin. This makes it very easy to see improvements, but those improvements don’t necessarily show up in aged skin.