Rivinius, C. Burning mouth syndrome: Identification, diagnosis, and treatment. J Am Acad.Nurse Pract. 2009;21(8):423-429. View abstract. Alpha-lipoic acid might slow blood clotting. Taking alpha-lipoic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding. Dementia in people with advanced HIV/AIDS. Taking alpha-lipoic acid by mouth has no effect on thinking problems in people with HIV. Mignini, F., Streccioni, V., Tomassoni, D., Traini, E., and Amenta, F. Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers. Clin Exp.Hypertens. 2007;29(8):575-586. View abstract.

Be watchful with this combination • Medications for diabetes (Antidiabetes drugs) interacts with ALPHA-LIPOIC ACID Liver disease in people who drink alcohol. Taking alpha-lipoic acid by mouth daily for up to 6 months does not improve liver function or reduce liver damage in people with alcohol-related liver disease. Vajdi M, Abbasalizad Farhangi M. Alpha‐lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta‐analysis of randomised placebo‐controlled clinical trials. Int J Clin Pract. 2020;74(6). doi:10.1111/ijcp.13493

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Emir DF, Ozturan IU, Yilmaz S. Alpha lipoic acid intoxication: An adult. The American Journal of Emergency Medicine. 2018. doi:10.1016/j.ajem.2018.03.022 Uchigata Y, Hirata Y Insulin autoimmune syndrome (IAS, Hirata disease). Ann Med Interne (Paris). (1999-Apr) Surgery: Alpha-lipoic acid can decrease blood sugar levels. Alpha-lipoic acid might interfere with blood sugar control during and after surgery. Stop taking alpha-lipoic acid 2 weeks before elective surgical procedures. Anti-Aging: One study found that a topical cream containing 5% alpha-lipoic acid could help reduce fine lines and wrinkles. Mitsui, Y., Schmelzer, J. D., Zollman, P. J., Mitsui, M., Tritschler, H. J., and Low, P. A. Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. J Neurol.Sci. 2-1-1999;163(1):11-16. View abstract.

Jibril AT, Jayedi A, Shab-Bidar S Efficacy and safety of oral alpha-lipoic acid supplementation for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized trials. Endocr Connect. (2022-Oct-01) Suo LN & Zhang D. Effects of lipoic acid and mecobalamin on diabetic peripheral neuropathy. Journal of Traditional Chinese Medicine. 2009;24:1104-1105. Kucukgoncu S, Zhou E, Lucas KB, Tek C. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obes Rev. 2017;18(5):594-601. doi:10.1111/obr.12528 For those concerned with cataracts and glaucoma, experiments with R-Alpha Lipoic Acid are delivering some exciting results!Lukaszuk, J. Schultz T. Prawitz A. and Hofmann E. R-Alpha Lipoic Acid Effect on HbA1c in Type-2 Diabetics. Journal of Complementary and Integrative Medicine 2009;6(1):1-14. Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Curr.Diab.Rep. 2011;11(2):142-148. View abstract. Ghibu, S., Richard, C., Delemasure, S., Vergely, C., Mogosan, C., and Muresan, A. [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases]. Ann Cardiol.Angeiol.(Paris) 2008;57(3):161-165. View abstract. a-ketoglutarate dehydrogenase. Lipoic acid is a cofactor for at least five enzyme systems, two of which peptide hormones, etc. The availability of the amino acid Cysteine is known as the rate-limiting factor in glutathione

Dementia Symptoms - Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation Am J Med Genet A. (2011 Aug) Breast-feeding: There isn't enough reliable information to know if alpha-lipoic acid is safe to use when breast-feeding. Stay on the safe side and avoid use. Chaparro, L. E., Wiffen, P. J., Moore, R. A., and Gilron, I. Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database.Syst.Rev. 2012;7:CD008943. View abstract. Spain R, Powers K, Murchison C, Heriza E, Winges K, Yadav V, Cameron M, Kim E, Horak F, Simon J, Bourdette D Lipoic acid in secondary progressive MS: A randomized controlled pilot trial. Neurol Neuroimmunol Neuroinflamm. (2017-Sep)

Products Containing R-ALA

Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. It serves vital functions at the cellular level, such as energy production. As long as you're healthy, the body can produce all the ALA it needs for these purposes. Despite that fact, there has been a lot of recent interest in using ALA supplements. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. Reducing the Risk of Heart Disease: A review of studies found that alpha-lipoic acid could help lower LDL (bad) cholesterol and triglycerides. end products (AGEs). AGEs increase with the length of hyperglycemia and are thought to be responsible for the kidney damage