Recently, considerably more powerful catalysts than DMAP with the nitrogen(s) incorporated into rings annelated to pyridine have been developed. 48 To our knowledge, however, they have not been used in conjunction with Boc 2O so far. 6 Summary and conclusion The highly increased reactivity of Boc 2O/ DMAP in comparison with that of Boc 2O has allowed the substitution of nitrogen-bound hydrogens far beyond such in ordinary amino functions. Of particular relevance in this context are amides and carbamates, due to the fact that many amino-protecting groups are of these types. In this respect the application of Boc 2O/ DMAP has paved the way for dual protection of amino functions. The reactions of Boc 2O with amines and alcohols in the presence and absence of DMAP have been investigated by Basel and Hassner with respect to products and mechanisms under widely varying conditions. 45 Different products were obtained depending on the ratio of reagents, polarity of the solvent and type of amine used. Without DMAP aliphatic amines gave Boc-derivatives in quantitative yields. In the presence of DMAP isocyanate formation was favoured at low temperatures, whereas otherwise in addition to Boc- and Boc 2-amine also urea and carbamic-carbonic anhydrides and related substances could be isolated. It was suggested that carbamic acids could occasionally play a role as reaction intermediates. Aliphatic alcohols gave O-Boc derivatives and symmetrical carbonates in the presence of DMAP. From cysteine methyl ester in the presence of DMAP, the N-Boc-, N, S-Boc 2- and N, N, S-Boc 3-derivatives could all be isolated. The obvious case for a delay in obtaining free pratique is that the crew are unwell which could be some contagious disease. For that reason, the standard Declaration of Health must be completed, answering questions about the health of the crew before the vessel can enter the port. Any positive answers are likely to cause delay and so the Master cannot say then that obtaining free pratique will be a formality. A Reaxys search (June 2013) for R-CO- N-R′(Boc), both R and R′ any group except hydrogen, corrected for R-N(Boc) 2 below that are obviously included, gave 7800 − 5600 = 2200 hits.

It has always been the case that a vessel needs to be legally ready to load or discharge the cargo on board, the health of the crew being one of the requirements to meet that legal readiness. It became recognised that, if the crew were healthy, confirming this would be a ‘mere formality’ and as such should not prevent the running of laytime. a) R. D. Connell, T. Rein, B. Åkermark and P. Helquist, J. Org. Chem., 1988, 53, 3845–3849 CrossRef CAS;

Cite this Entry

P. G. M. Wuts and T. W. Greene, Greene’s Protective Groups in Organic Synthesis, 4th ed., Wiley, Hoboken, 2007, Chapter 7 Search PubMed. En 1547, dans la préface de La Geometrie practique, Bovelles remercie Oronce Fine pour l'aide qu'il lui a apportée dans la confection des gravures de son livre. A question over who granted pratique arose with the Ruby Princess COVID-19 incident. [6] See also [ edit ] If the Master reasonably decides free pratique is only going to be a formality and not cause a delay, he can issue the NOR which remains valid even if there is then a subsequent delay. L. Grehn, K. Gunnarsson and U. Ragnarsson, Acta Chem. Scand., Ser. B, 1987, B41, 18–23 CrossRef CAS and reference therein.

An early attempt to react acetanilide with dimethyl dicarbonate in the presence of DMAP was unsuccessful 13 but with 4-thiazolidinone as substrate a methyloxycarbonyl derivative was obtained, although in lower yield than with Boc 2O. 23 The latter substrate with Cbz 2O/ DMAP also afforded the corresponding Cbz-protected product. 23 Of other analogous reagents investigated only di-1-adamantyl dicarbonate with DMAP was preparatively useful. 47 pratique”, in Trésor de la langue française informatisé [Digitized Treasury of the French Language ], 2012. In London Arbitration 14/86time would begin, amongst other things, when “in free pratique”. The vessel tendered NOR on 6 June but had to wait at anchorage until 20 June, arriving at berth that day and being granted free pratique. The owner’s reliance on The Delian Spiritalso failed here because, despite the fact that the crew were indisputably healthy when the NOR was tendered on 6 June, there was an express requirement that she be in free pratique. The same argument failed in London Arbitration 1/00.This etymology is missing or incomplete. Please add to it, or discuss it at the Etymology scriptorium.) Noun [ edit ] experience C’est un homme qui a la pratique des affaires. ― This is a man with business experience. f) J. Zheng, B. Yin, W. Huang, X. Li, H. Yao, Z. Liu, J. Zhang and S. Jiang, Tetrahedron Lett., 2009, 50, 5094–5097 CrossRef CAS. P. M. T. Ferreira, H. L. S. Maia, L. S. Monteiro and J. Sacramento, J. Chem. Soc., Perkin Trans. 1, 1999, 3697–3703 RSC. b) S. Bhatia, S. Singh, R. Kumar, A. Kumar, C. E. Olsen and A. K. Prasad, Indian J. Chem., 2013, 52B, 379–386 Search PubMed.